Originally, Tumacácori was an O'odham settlement. In 1691, the Jesuit missionary Eusebio Francisco Kino founded mission San Cayento de Tumacácori on the east bank of the Santa Cruz River. The building of the currently standing mission, San José de Tumacácori, was initially started in 1800 before the church was eventually abandoned in 1848. For years, Tumacácori was a meeting place for Jesuits and multiple Native communities, including the O'odham, Yaqui, and Apache. Today the Mission still exists as a crossroad between people, their cultures, and their history. 

For more information, visit Tumacácori National Historic Park.